Getting a bit far afield from Unixes, but A Quick Rundown Of Instruction Sets I Have Known, more or less in the order I learned them:
6502: you never forget your first love, and, sure, it's constrained, but it's elegant and concise and I still adore it.
68k: Lovely. I used it before I ever used the PDP-11, but in retrospect it's like the PDP-11 but more so. Roomy, comfortable, regular. Too bad it lost to x86 in the marketplace.
8051: I mean, OK, I get it, you need a low-cost embedded architecture and it's the 1980s, but...yuck.
x86-and-descendents: the less said the better. Maybe I just don't like Intel's designs?
SPARC: It's not bad. Having lots of registers is nice. But by the time it came along compilers were good enough that I never actually needed to use it in anger.
S/360-and-descendents: The S/360 is OK, even nice, in a very 1960s IBM way. And then its evolution just KEPT adding ever more baroque filigrees onto it. Don't get me wrong, I love SIE, because I love VM, but even that is kind of a bag on the side, and by the time you get to System z...this is what happens when you don't start over from a clean sheet every so often.
PDP-11: There's a very good reason it was used as a model architecture in coursework for decades. Also regular and comfortable.
TI-99/4A (more or less TI 9900): I like microcode as much as anyone but honestly this is pretty silly here, folks.
These days I'm kinda sorta poking at RISC-V and ARM. Not that I need to, but they seem nifty.
Adam